8d ago
Background proteome correction promotes confident identification of dynamic protein-protein interactions between different biological contexts
Brunelli · M. A. · Morishita-Cartwright · L. · Clark · N. M. · Mani · D. R. · +2 more
Abstract
Affinity purification-mass spectrometry (AP-MS) enables the characterization of protein-protein interactions (PPIs), and the ease and sensitivity of such experiments has progressively increased. Beyond steady-state interactions of target proteins, a strong interest has emerged in monitoring how PPIs change upon significant biological perturbations, such as in disease contexts or small molecule modulation of the target protein. These perturbations likely not only induce PPI changes but can also l
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