AI RESEARCHarXiv13d ago

[Correspondence] Anti-β amyloid immunotherapy: not clinically meaningful

Francesco Nonino · Edo Richard

Abstract

We thank Nick C Fox and colleagues for their response1 to our study on the use of amyloid β-targeting monoclonal antibodies for Alzheimer's disease.2 All amyloid β-targeting monoclonal antibodies, although binding to different epitopes of the β-amyloid protein, share the same objective: removing β-amyloid from the brain. Some antibodies other than lecanemab and donanemab also do so successfully, as established in several trials.3,4 Data from trials on agents sharing the same pathophysiological t

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