AI RESEARCHarXiv13d ago

[Correspondence] Why is depression divisive in dementia prevention?

Harry Costello · Jemma Hazan · Yuto Satake · Robert Howard

Abstract

Dementia prevention is a global health priority. The 2024 update of the Lancet Commission on dementia estimated that 14 modifiable risk factors account for up to 45% of dementia cases, with 3% of these cases attributable to depression, and recommended more effective treatment.1 However, 2026 WHO dementia prevention guidelines omit depression, citing insufficient causal evidence.2 Such caution is inconsistent with recommendations for other risk factors (eg, diabetes and social activity), for whic

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