10d ago
dnoise: Fast Native Data Reduction for Bruker timsTOF
Garrett · P. T. · Diedrich · J. K. · Yates · J. R.
Abstract
Bruker timsTOF acquisitions produce dense native .d files whose storage, transfer, and archival become substantial at high throughput. We present dnoise, an open-source Rust tool that removes points directly from timsTOF frames and writes a native-compatible .d directory. dnoise retains ions that form coherent streaks across the ion-mobility dimension and applies acquisition-aware gates to signal that cannot be selected for fragmentation. On a three-species benchmark spanning ddaPASEF and diaPAS
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