10d ago
Hyperglycemia Activates Retinal Photoreceptors to Induce Neuroglial Inflammation
Huerta · I. D. l. · Uddin · M. I. · Penn · J. S.
Abstract
Abstract Diabetic retinopathy (DR) is a major cause of vision loss in working-age adults. Accumulating evidence suggests that retinal photoreceptors contribute to the initiation and progression of diabetic retinopathy. In this study, we investigated whether hyperglycemia directly alters photoreceptor signaling and whether photoreceptor-derived inflammatory mediators activate downstream Muller glial cells. Primary photoreceptors were isolated from adult mice and cultured with normal glucose, high
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