9d ago
Immune Checkpoint Blockade Modifies Drug-Associated Toxicity Across Phenotypes and Time
Mukherjee · E. M. · Asiaee · A. · Park · D. · Krantz · M. S. · +6 more
Abstract
Importance: Immune checkpoint inhibitors (ICIs) produce diverse immune toxicities, but whether checkpoint blockade also modifies associations between other drugs and adverse events is poorly understood. Objective: To define ICI-associated toxicity organization and determine whether drug-associated adverse events and onset vary with ICI exposure and checkpoint pathway. Design and Setting: Cross-sectional analysis of deduplicated FAERS reports from 2016 through 2025; analyses performed in 2026. Pa
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