8d ago
Probing the transcriptome response to shivering in skeletal muscle using a multilayered bioinformatics approach
Kalkhoven · E. · Baak · R. E. · Hooiveld · G. J. E. J. · Schrauwen · P. · +8 more
Abstract
Cold acclimation holds therapeutic potential for improving metabolic health. We previously demonstrated that repeated cold-induced shivering enhances insulin sensitivity in humans. However, the molecular pathways that underlie the skeletal muscle shivering response, and how these relate to beneficial physiological effects, remain poorly understood. In this study, we combined complementary bioinformatics approaches to allow in-depth analysis of the transcriptomic response of human skeletal muscle
Discussion · 0
Sign in to join the discussion.