9d ago
Sex Differences in the Impact of Allosensitization on Waitlist Access and Post-Transplant Outcomes in Adults with Congenital Heart Disease
Joseph · A. · Kearney · K. · Henricks · C. · Morgan · J. L. · +20 more
Abstract
Background: Adult congenital heart disease (ACHD) patients are prone to HLA-antibody formation from multiple surgeries, transfusions, and prosthetic surgical material. Females with ACHD may accrue additional, non-surgical alloantigen exposure. Whether sex modifies the impact of allosensitization on heart transplant (HT) access and outcomes in ACHD remains unknown. Methods: We retrospectively analyzed the OPTN/UNOS registry of adults with ACHD listed for first-time HT (2018-2025). Sensitization w
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