10d ago
Spacing theta-burst stimulation enhances synaptic potentiation in the vulnerable prefrontal cortex
Zolis · A. · Hsieh · A. H.-Y. · Venkatesan · S. · Ingram · R. · +10 more
Abstract
Neuromodulation with intermittent theta-burst stimulation (iTBS) is a clinical treatment for major depression. One postulated mechanism of iTBS is to strengthen the synaptic connections which activate the prefrontal cortex to regulate mood. With ex vivo electrical stimulation and neuronal calcium imaging, we demonstrate that a common, clinical iTBS pattern (600-stimuli, 3-min) reliably strengthens the synaptic recruitment of the adult mouse prefrontal cortex. This synaptic potentiation, however
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