9d ago
The accuracy of urine-based mycobacterial antigens to detect childhood tuberculosis using an ultrasensitive immunoassay
Nkereuwem · E. · Misaghian · S. · Jaganath · D. · Calderon · R. I. · +39 more
Abstract
Background. Urine-based testing offers a promising non-sputum approach for diagnosing paediatric tuberculosis. However, the currently available lipoarabinomannan (LAM) assay shows limited sensitivity in children and is primarily indicated for those living with HIV. Co-detection of LAM with Mycobacterium tuberculosis (Mtb) proteins in urine could provide complementary pathogen-derived biomarkers that improve diagnostic performance. Methods. We developed an ultrasensitive multiplex electrochemilum
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