10d ago
The Microbiota Dictates Vendor-Derived Differences in a Murine Clostridioides difficile Infection Model
Keogh · L. · Dridi · L. · Thurairajah · B. · Shamash · M. · +6 more
Abstract
Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated infectious diarrhea and remains a major burden to healthcare systems worldwide. The development of novel therapeutics for CDI requires robust and reproducible preclinical models. However, the microbiota has emerged as a major source of variability in animal studies. Here, we found that genetically similar mice obtained from two commercial vendors, Jackson Laboratory (JAX) and Charles River Laboratories (CRL),
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